![]() ![]() ![]() Cognitive distortions of anxious depression feature a barrage of negative self-appraisals that lead to feelings of hopelessness and/or pessimism, guilt, worthlessness and/or thoughts of suicide, or even suicide attempts in major depressive disorder. Most forms of depression, including anxious depression, are associated with a range of symptom clusters including the hallmark emotional problems of persistent sadness, anxiety or anxious feelings ( American Psychiatric Association, 2000). In this project, we explored the possibility that REM sleep physiology differentially impacts the neurocognitive symptoms of anxious depression including executive cognitive dysfunction, distorted evaluative appraisals of self, unpleasant dream content and biased emotional memory processing. The replicated finding that both selective REM sleep and total sleep deprivation provide dramatic and immediate (though temporary) relief for some people with mood disorder ( Giedke and Schwarzler, 2002 Vogel, 1975 Wu et al., 2008) supports the claim that REM does indeed play some role in production of at least some clinical symptoms in some people with mood disorder. Although REM sleep has long been known to be altered in depression, including anxious depression, its role in production of the symptomology of mood disorder has never been adequately clarified (for reviews see Armitage, 2007 Nutt et al., 2008 Tsuno et al., 2005). ![]()
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